APOA5

APOA5
Identifiers
Aliases	APOA5, APOAV, RAP3, apolipoprotein A5
External IDs	OMIM: 606368; MGI: 1913363; HomoloGene: 14197; GeneCards: APOA5; OMA:APOA5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	116,792,420 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	46,183,217 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; gonad; ; intestinal epithelium; ; urinary system; ; blood; ; wall of uterus; ; hippocampal formation; ; kidney; ; myometrium;
	Top expressed in
	left lobe of liver; ; gallbladder; ; yolk sac; ; sexually immature organism; ; embryo; ; embryo; ; Ileal epithelium; ; medial head of gastrocnemius muscle; ; cingulate gyrus; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparin binding; lipoprotein particle receptor binding; phosphatidylcholine binding; lipoprotein lipase activator activity; lipase binding; lipase activator activity; low-density lipoprotein particle receptor binding; cholesterol binding; enzyme binding; enzyme activator activity; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipid binding; cholesterol transfer activity; lipid binding;
Cellular component	blood microparticle; chylomicron; very-low-density lipoprotein particle; extracellular region; low-density lipoprotein particle; high-density lipoprotein particle; extracellular space; endoplasmic reticulum lumen;
Biological process	neuron projection regeneration; positive regulation of receptor-mediated endocytosis; lipid transport; positive regulation of triglyceride catabolic process; tissue regeneration; positive regulation of cholesterol esterification; phospholipid efflux; positive regulation of lipid catabolic process; positive regulation of lipoprotein lipase activity; high-density lipoprotein particle assembly; positive regulation of fatty acid biosynthetic process; triglyceride catabolic process; regulation of intestinal cholesterol absorption; cholesterol efflux; cholesterol biosynthetic process; cholesterol homeostasis; acylglycerol homeostasis; positive regulation of very-low-density lipoprotein particle remodeling; phosphatidylcholine metabolic process; triglyceride metabolic process; triglyceride-rich lipoprotein particle remodeling; triglyceride homeostasis; reverse cholesterol transport; regulation of lipid metabolic process; lipoprotein metabolic process; post-translational protein modification; regulation of cholesterol transport; very-low-density lipoprotein particle remodeling; positive regulation of lipid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	116519
	66113
	ENSG00000110243
	ENSMUSG00000032079
	Q6Q788
	Q8C7G5
	NM_052968; NM_001166598; NM_001371904
	NM_080434; NM_001348095
	NP_001160070; NP_443200; NP_001358833
	NP_536682; NP_001335024
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. It is significantly expressed in liver. The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors. Considering its association with lipoprotein levels, APOA5 is implicated in metabolic syndrome. The APOA5 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.