| AQP3 |
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| Identifiers |
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| Aliases | AQP3, AQP-3, GIL, aquaporin 3 (Gill blood group) |
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| External IDs | OMIM: 600170; MGI: 1333777; HomoloGene: 21025; GeneCards: AQP3; OMA:AQP3 - orthologs |
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| Gene location (Human) |
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| | Chr. | Chromosome 9 (human) |
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| | Band | 9p13.3 | Start | 33,441,156 bp |
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| End | 33,447,596 bp |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 4 (mouse) |
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| | Band | 4|4 A5 | Start | 41,092,722 bp |
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| End | 41,098,183 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - nasal epithelium
- gingival epithelium
- mucosa of pharynx
- epithelium of nasopharynx
- parotid gland
- human penis
- palpebral conjunctiva
- vulva
- oral cavity
- nipple
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| | Top expressed in | - lip
- olfactory epithelium
- transitional epithelium of urinary bladder
- yolk sac
- esophagus
- right kidney
- mucous cell of stomach
- skin of external ear
- conjunctival fornix
- cornea
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
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| Wikidata |
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Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers. In the kidney, aquaporin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. This protein is also a determinant for the GIL blood group system.
Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).
