Adrenomedullin

ADM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FLY, 2L7S, 4RWF
Identifiers
Aliases	ADM, Adm, AM, PAMP, adrenomedullin
External IDs	OMIM: 103275; MGI: 108058; HomoloGene: 873; GeneCards: ADM; OMA:ADM - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	10,307,397 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	110,229,027 bp
RNA expression pattern
	Top expressed in
	vena cava; ; beta cell; ; pericardium; ; cartilage tissue; ; saphenous vein; ; human penis; ; stromal cell of endometrium; ; decidua; ; synovial joint; ; glomerulus;
	Top expressed in
	decidua; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; gastrula; ; superior cervical ganglion; ; epithelium of stomach; ; atrium; ; trophoblast giant cell; ; renal corpuscle; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; hormone activity; adrenomedullin receptor binding; protein binding;
Cellular component	extracellular region; cytoplasm; extracellular space;
Biological process	negative regulation of cell population proliferation; response to hypoxia; neural tube closure; branching involved in labyrinthine layer morphogenesis; antibacterial humoral response; defense response to Gram-negative bacterium; receptor internalization; blood circulation; signal transduction; animal organ regeneration; cell-cell signaling; response to lipopolysaccharide; vascular associated smooth muscle cell development; defense response to Gram-positive bacterium; positive regulation of cytosolic calcium ion concentration; vasculogenesis; negative regulation of vasoconstriction; G protein-coupled receptor internalization; cAMP-mediated signaling; calcium ion homeostasis; response to starvation; heart development; regulation of the force of heart contraction; positive regulation of apoptotic process; response to yeast; response to cold; positive regulation of vasculogenesis; neuron projection regeneration; hormone secretion; antifungal humoral response; positive regulation of cell population proliferation; response to glucocorticoid; developmental growth; ageing; progesterone biosynthetic process; negative regulation of vascular permeability; androgen metabolic process; response to insulin; positive regulation of angiogenesis; response to organic substance; odontogenesis of dentin-containing tooth; spongiotrophoblast layer development; female pregnancy; response to wounding; cAMP biosynthetic process; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of systemic arterial blood pressure; positive regulation of heart rate; regulation of urine volume; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of signaling receptor activity; amylin receptor signaling pathway; adrenomedullin receptor signaling pathway; inflammatory response; positive regulation of progesterone biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	133
	11535
	ENSG00000148926
	ENSMUSG00000030790
	P35318
	P97297
	NM_001124
	NM_009627
	NP_001115
	NP_033757
	Wikidata
View/Edit Human	View/Edit Mouse

Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inflammatory and tissue-protective properties.

In humans ADM is encoded by the ADM gene. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.