Apolipoprotein C-III

APOC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JQ3
Identifiers
Aliases	APOC3, APOCIII, HALP2, apolipoprotein C3, Apo-C3, ApoC-3, apolipoprotein CIII, Apo-CIII, IPR008403, apolipoprotein C-III
External IDs	OMIM: 107720; MGI: 88055; HomoloGene: 81615; GeneCards: APOC3; OMA:APOC3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	116,833,072 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	46,146,934 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; mucosa of ileum; ; duodenum; ; gonad; ; amniotic fluid; ; human kidney; ; epithelium of colon; ; metanephros; ; left uterine tube;
	Top expressed in
	left lobe of liver; ; duodenum; ; jejunum; ; migratory enteric neural crest cell; ; yolk sac; ; ileum; ; right kidney; ; proximal tubule; ; median eminence; ; intestinal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lipid binding; lipase inhibitor activity; enzyme regulator activity; high-density lipoprotein particle receptor binding; cholesterol binding; phospholipid binding;
Cellular component	chylomicron; very-low-density lipoprotein particle; spherical high-density lipoprotein particle; extracellular region; early endosome; extracellular exosome; intermediate-density lipoprotein particle; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	negative regulation of cholesterol import; G protein-coupled receptor signaling pathway; negative regulation of very-low-density lipoprotein particle remodeling; lipid transport; chylomicron remnant clearance; negative regulation of fatty acid biosynthetic process; regulation of Cdc42 protein signal transduction; lipid metabolism; negative regulation of high-density lipoprotein particle clearance; phospholipid efflux; negative regulation of low-density lipoprotein particle clearance; negative regulation of very-low-density lipoprotein particle clearance; retinoid metabolic process; negative regulation of receptor-mediated endocytosis; lipid catabolic process; cholesterol efflux; negative regulation of lipoprotein lipase activity; cholesterol homeostasis; very-low-density lipoprotein particle assembly; negative regulation of triglyceride catabolic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; reverse cholesterol transport; triglyceride homeostasis; triglyceride metabolic process; triglyceride catabolic process; chylomicron remodeling; high-density lipoprotein particle remodeling; chylomicron assembly; lipoprotein metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	345
	11814
	ENSG00000110245
	ENSMUSG00000032081
	P02656
	P33622
	NM_000040
	NM_023114; NM_001289755; NM_001289756; NM_001289833
	NP_000031
	NP_001276684; NP_001276685; NP_001276762; NP_075603
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as chylomicrons, very low density lipoprotein (VLDL), and remnant cholesterol.