C1-inhibitor

SERPING1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OAY
Identifiers
Aliases	SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2, serpin family G member 1
External IDs	OMIM: 606860; MGI: 894696; HomoloGene: 44; GeneCards: SERPING1; OMA:SERPING1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	57,619,171 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,605,788 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right lung; ; right coronary artery; ; gastric mucosa; ; Descending thoracic aorta; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; left uterine tube; ; right ovary;
	Top expressed in
	left lobe of liver; ; gastrula; ; carotid body; ; decidua; ; ankle; ; right lung; ; right lung lobe; ; efferent ductule; ; white adipose tissue; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	blood microparticle; extracellular region; extracellular exosome; platelet alpha granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	hemostasis; blood coagulation, intrinsic pathway; negative regulation of peptidase activity; fibrinolysis; immune system process; ageing; platelet degranulation; blood circulation; negative regulation of complement activation, lectin pathway; complement activation, classical pathway; innate immune response; negative regulation of endopeptidase activity; blood coagulation; regulation of complement activation; regulation of blood coagulation; negative regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	710
	12258
	ENSG00000149131
	ENSMUSG00000023224
	P05155
	P97290
	NM_001032295; NM_000062
	NM_009776
	NP_000053; NP_001027466
	NP_033906
	Wikidata
View/Edit Human	View/Edit Mouse

C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major regulator of the contact system (PK, FXIIa, and FXIa).