CCR5

CCR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L87, 2RLL, 2RRS, 2MZX, 4MBS
Identifiers
Aliases	CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5
External IDs	OMIM: 601373; MGI: 107182; HomoloGene: 37325; GeneCards: CCR5; OMA:CCR5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,376,206 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,947,736 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; parietal pleura; ; visceral pleura; ; palpebral conjunctiva; ; granulocyte; ; germinal epithelium; ; mucosa of urinary bladder; ; appendix; ; superficial temporal artery; ; jejunal mucosa;
	Top expressed in
	lumbar subsegment of spinal cord; ; morula; ; lumbar spinal ganglion; ; blood; ; embryo; ; lymph node; ; mesenteric lymph nodes; ; submandibular gland; ; blastocyst; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; coreceptor activity; chemokine (C-C motif) ligand 5 binding; virus receptor activity; signal transducer activity; protein binding; chemokine receptor activity; C-C chemokine receptor activity; actin binding; phosphatidylinositol phospholipase C activity; C-C chemokine binding; chemokine binding;
Cellular component	cytoplasm; integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; cell surface;
Biological process	G protein-coupled receptor signaling pathway; signaling; response to cholesterol; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; dendritic cell chemotaxis; MAPK cascade; chemotaxis; cellular defense response; cell surface receptor signaling pathway; immune response; inflammatory response; cellular response to lipopolysaccharide; calcium ion transport; calcium-mediated signaling; signal transduction; fusion of virus membrane with host plasma membrane; chemokine-mediated signaling pathway; viral process; defense response; negative regulation of macrophage apoptotic process; cytokine-mediated signaling pathway; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1234
	12774
	ENSG00000160791
	ENSMUSG00000079227
	P51681
	P51682
	NM_001100168; NM_000579; NM_001394783
	NM_009917
	NP_000570; NP_001093638
	NP_034047
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.

In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation, resulting in the genetic deletion of a portion of the CCR5 gene. Homozygous carriers of this mutation are resistant to infection by macrophage-tropic (M-tropic) strains of HIV-1.