CYP1A2

CYP1A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HI4
Identifiers
Aliases	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
External IDs	OMIM: 124060; MGI: 88589; HomoloGene: 68082; GeneCards: CYP1A2; OMA:CYP1A2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,756,607 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,590,986 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; right lobe of liver; ; superficial temporal artery; ; cardia; ; nipple; ; vena cava; ; mucosa of paranasal sinus; ; subthalamic nucleus; ; sperm; ; ventral tegmental area;
	Top expressed in
	left lobe of liver; ; olfactory epithelium; ; gallbladder; ; sexually immature organism; ; duodenum; ; thoracic diaphragm; ; medial head of gastrocnemius muscle; ; right lung lobe; ; thymus; ; pancreas;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; demethylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; metal ion binding; caffeine oxidase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; enzyme binding; oxidoreductase activity; aromatase activity; electron transfer activity; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum;
Biological process	response to immobilization stress; toxin metabolic process; steroid metabolic process; response to estradiol; alkaloid metabolic process; response to organic cyclic compound; lung development; lipid metabolism; epoxygenase P450 pathway; cellular response to cadmium ion; post-embryonic development; monocarboxylic acid metabolic process; response to organic substance; oxidative demethylation; response to lipopolysaccharide; methylation; steroid catabolic process; omega-hydroxylase P450 pathway; dibenzo-p-dioxin metabolic process; heterocycle metabolic process; cellular respiration; cellular aromatic compound metabolic process; regulation of gene expression; hydrogen peroxide biosynthetic process; monoterpenoid metabolic process; xenobiotic metabolic process; porphyrin-containing compound metabolic process; toxin biosynthetic process; cellular response to copper ion; electron transport chain; long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1544
	13077
	ENSG00000140505
	ENSMUSG00000032310
	P05177
	P00186
	NM_000761
	NM_009993
	NP_000752
	NP_034123
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene.