Dopamine receptor D2

DRD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6CM4
Identifiers
Aliases	DRD2, D2DR, D2R, dopamine receptor D2
External IDs	OMIM: 126450; MGI: 94924; HomoloGene: 22561; GeneCards: DRD2; OMA:DRD2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,475,691 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	49,319,477 bp
RNA expression pattern
	Top expressed in
	putamen; ; nucleus accumbens; ; testicle; ; pituitary gland; ; caudate nucleus; ; anterior pituitary; ; triceps brachii muscle; ; pars compacta; ; pars reticulata; ; ventral tegmental area;
	Top expressed in
	superior frontal gyrus; ; striatum of neuraxis; ; dorsal striatum; ; nucleus accumbens; ; olfactory epithelium; ; lumbar subsegment of spinal cord; ; neural layer of retina; ; olfactory tubercle; ; embryo; ; ankle joint;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; potassium channel regulator activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; identical protein binding; dopamine neurotransmitter receptor activity; G protein-coupled receptor activity; protein binding; signal transducer activity; adrenergic receptor activity; dopamine binding; signaling receptor binding; ionotropic glutamate receptor binding; protein heterodimerization activity;
Cellular component	cytoplasmic vesicle; sperm flagellum; endocytic vesicle; acrosomal vesicle; dendritic spine; synaptic vesicle membrane; perikaryon; plasma membrane; dendrite; ciliary membrane; axon terminus; integral component of membrane; postsynaptic density; membrane; lateral plasma membrane; axon; intracellular anatomical structure; non-motile cilium; integral component of plasma membrane; dopaminergic synapse; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	negative regulation of cell population proliferation; temperature homeostasis; adenylate cyclase-inhibiting dopamine receptor signaling pathway; adenohypophysis development; circadian regulation of gene expression; response to toxic substance; regulation of dopamine secretion; response to cocaine; response to amphetamine; sensory perception of smell; locomotory behavior; positive regulation of urine volume; response to ethanol; axonogenesis; response to inactivity; phospholipase C-activating dopamine receptor signaling pathway; modulation of chemical synaptic transmission; grooming behavior; negative regulation of protein kinase B signaling; associative learning; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; regulation of dopamine uptake involved in synaptic transmission; regulation of synaptic transmission, GABAergic; positive regulation of dopamine uptake involved in synaptic transmission; signal transduction; Wnt signaling pathway; adult walking behavior; branching morphogenesis of a nerve; negative regulation of cytosolic calcium ion concentration; negative regulation of innate immune response; regulation of phosphoprotein phosphatase activity; acid secretion; feeding behavior; positive regulation of G protein-coupled receptor signaling pathway; response to axon injury; striatum development; synaptic transmission, dopaminergic; nervous system process involved in regulation of systemic arterial blood pressure; peristalsis; regulation of long-term neuronal synaptic plasticity; activation of protein kinase activity; positive regulation of growth hormone secretion; regulation of sodium ion transport; forebrain development; response to light stimulus; orbitofrontal cortex development; prepulse inhibition; response to morphine; response to iron ion; positive regulation of ERK1 and ERK2 cascade; long-term memory; positive regulation of renal sodium excretion; negative regulation of insulin secretion; neuron-neuron synaptic transmission; intracellular signal transduction; auditory behavior; behavioral response to ethanol; regulation of heart rate; adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of cytokinesis; regulation of potassium ion transport; pigmentation; cellular calcium ion homeostasis; dopamine metabolic process; response to nicotine; regulation of MAPK cascade; response to histamine; negative regulation of synaptic transmission, glutamatergic; response to hypoxia; negative regulation of circadian sleep/wake cycle, sleep; negative regulation of protein secretion; synapse assembly; regulation of locomotion involved in locomotory behavior; dopamine receptor signaling pathway; negative regulation of dopamine receptor signaling pathway; startle response; positive regulation of receptor internalization; protein localization; arachidonic acid secretion; positive regulation of transcription by RNA polymerase II; G protein-coupled receptor internalization; positive regulation of multicellular organism growth; positive regulation of long-term synaptic potentiation; negative regulation of dopamine secretion; adult behavior; cerebral cortex GABAergic interneuron migration; regulation of synapse structural plasticity; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; visual learning; negative regulation of cell migration; behavioral response to cocaine; positive regulation of neuroblast proliferation; negative regulation of blood pressure; release of sequestered calcium ion into cytosol; negative regulation of voltage-gated calcium channel activity; G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; excitatory postsynaptic potential; negative regulation of protein phosphorylation; autophagy; positive regulation of neurogenesis; negative regulation of cell death; drinking behavior; adrenergic receptor signaling pathway; regulation of neurotransmitter uptake; postsynaptic modulation of chemical synaptic transmission; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1813
	13489
	ENSG00000149295
	ENSMUSG00000032259
	P14416
	P61168
	NM_016574; NM_000795
	NM_010077
	NP_000786; NP_057658; NP_000786.1
	NP_034207
	Wikidata
View/Edit Human	View/Edit Mouse

Dopamine receptor D₂, also known as D₂R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D₂ receptor. The dopamine D₂ receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined.