Dextromoramide

Dextromoramide
	Above: molecular structure of dextromoramide. Below: 3D representation of a dextromoramide molecule.
Clinical data
Trade names	Palfium
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: C;
Routes of; administration	Oral, Rectal, Intravenous, Insufflation
ATC code	N02AC01 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage II (Authorized trade only, not prescriptible); US: Schedule I;
Pharmacokinetic data
Bioavailability	>75%
Protein binding	High
Metabolism	Liver, partly mediated by CYP3A4
Elimination half-life	3.5 hours
Excretion	Urine, faeces
Identifiers
	IUPAC name (3S)-3-methyl-4-morpholin-4-yl-2,2-diphenyl-1-pyrrolidin-1-yl-butan-1-one;
CAS Number	357-56-2 ;
PubChem CID	92943;
DrugBank	DB01529 ;
ChemSpider	83901 ;
UNII	9S4S6CIY83;
KEGG	D07287 ;
ChEBI	CHEBI:74274 ;
ChEMBL	ChEMBL431928 ;
CompTox Dashboard (EPA)	DTXSID8022909 ;
ECHA InfoCard	100.006.013
Chemical and physical data
Formula	C25H32N2O2
Molar mass	392.543 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](CN1CCOCC1)C(C(=O)N1CCCC1)(c1ccccc1)c1ccccc1;
	InChI InChI=1S/C25H32N2O2/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27/h2-7,10-13,21H,8-9,14-20H2,1H3/t21-/m1/s1 ; Key:INUNXTSAACVKJS-OAQYLSRUSA-N ;
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Dextromoramide (Palfium, Palphium, Jetrium, Dimorlin) is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties and by the criminal law of individual nations, and is usually prescribed only in the Netherlands.