| ENAM |
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| Identifiers |
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| Aliases | ENAM, AIH2, AI1C, ADAI, enamelin |
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| External IDs | OMIM: 606585; MGI: 1333772; HomoloGene: 9698; GeneCards: ENAM; OMA:ENAM - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 5 (mouse) |
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| | Band | 5|5 E1 | Start | 88,635,834 bp |
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| End | 88,653,908 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - testicle
- islet of Langerhans
- vastus lateralis muscle
- striated muscle tissue
- biceps brachii
- Skeletal muscle tissue of biceps brachii
- human kidney
- deltoid muscle
- corpus epididymis
- buccal mucosa cell
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| | Top expressed in | - molar
- tracheobronchial tree
- intestinal villus
- Ileal epithelium
- perirhinal cortex
- choroid plexus of fourth ventricle
- CA3 field
- lactiferous gland
- inferior colliculi
- superior colliculus
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
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| Wikidata |
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Enamelin is an enamel matrix protein (EMPs), that in humans is encoded by the ENAM gene. It is part of the non-amelogenins, which comprise 10% of the total enamel matrix proteins. It is one of the key proteins thought to be involved in amelogenesis (enamel development). The formation of enamel's intricate architecture is thought to be rigorously controlled in ameloblasts through interactions of various organic matrix protein molecules that include: enamelin, amelogenin, ameloblastin, tuftelin, dentine sialophosphoprotein, and a variety of enzymes. Enamelin is the largest protein (~168kDa) in the enamel matrix of developing teeth and is the least abundant (encompasses approximately 1-5%) of total enamel matrix proteins. It is present predominantly at the growing enamel surface.
