FOXC2

FOXC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D5V
Identifiers
Aliases	FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
External IDs	OMIM: 602402; MGI: 1347481; HomoloGene: 21091; GeneCards: FOXC2; OMA:FOXC2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	86,569,728 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	121,845,634 bp
RNA expression pattern
	Top expressed in
	vena cava; ; palpebral conjunctiva; ; popliteal artery; ; trigeminal ganglion; ; tibial arteries; ; urethra; ; ascending aorta; ; spinal ganglia; ; Descending thoracic aorta; ; cardiac muscle tissue of right atrium;
	Top expressed in
	aortic arches; ; ascending aorta; ; fifth metatarsal bone; ; renal corpuscle; ; optic nerve; ; aortic valve; ; fourth metatarsal bone; ; somite; ; sclerotome; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; identical protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chromatin DNA binding; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; nucleoplasm; nuclear body;
Biological process	Notch signaling pathway; somitogenesis; embryonic skeletal system morphogenesis; skeletal system development; insulin receptor signaling pathway; ureteric bud development; regulation of transcription, DNA-templated; positive regulation of cell migration involved in sprouting angiogenesis; neural crest cell development; paraxial mesoderm formation; paraxial mesodermal cell fate commitment; ossification; lymphangiogenesis; collagen fibril organization; kidney development; glomerular mesangial cell development; heart morphogenesis; negative regulation of transcription by RNA polymerase II; cardiac muscle cell proliferation; lymph vessel development; transcription, DNA-templated; embryonic heart tube development; positive regulation of endothelial cell migration; positive regulation of transcription, DNA-templated; multicellular organism development; ventricular cardiac muscle tissue morphogenesis; heart development; blood vessel remodeling; vascular endothelial growth factor receptor signaling pathway; blood vessel development; positive regulation of vascular wound healing; artery morphogenesis; branching involved in blood vessel morphogenesis; glomerular visceral epithelial cell differentiation; response to hormone; embryonic viscerocranium morphogenesis; embryonic cranial skeleton morphogenesis; camera-type eye development; glomerular endothelium development; positive regulation of cell adhesion mediated by integrin; mesoderm development; regulation of organ growth; metanephros development; cell population proliferation; positive regulation of transcription by RNA polymerase II; negative regulation of apoptotic process involved in outflow tract morphogenesis; transcription by RNA polymerase II; cell differentiation; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2303
	14234
	ENSG00000176692
	ENSMUSG00000046714
	Q99958
	Q61850
	NM_005251
	NM_013519
	NP_005242
	NP_038547
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.