Follistatin

FST
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HH2, 2B0U, 2P6A
Identifiers
Aliases	FST, FS, follistatin
External IDs	OMIM: 136470; MGI: 95586; HomoloGene: 7324; GeneCards: FST; OMA:FST - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	53,487,134 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	114,595,487 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; buccal mucosa cell; ; right lobe of liver; ; oocyte; ; secondary oocyte; ; mucosa of urinary bladder; ; Achilles tendon; ; pericardium; ; subcutaneous adipose tissue; ; gastric mucosa;
	Top expressed in
	cumulus cell; ; gastrula; ; primitive streak; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; calvaria; ; ovary; ; decidua; ; epiblast; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; protein binding; signal transducer activity; activin binding; activin receptor antagonist activity;
Cellular component	extracellular region;
Biological process	positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; hematopoietic progenitor cell differentiation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10468
	14313
	ENSG00000134363
	ENSMUSG00000021765
	P19883
	P47931
	NM_006350; NM_013409
	NM_008046; NM_001301373; NM_001301375
	NP_006341; NP_037541
	NP_001288302; NP_001288304; NP_032072
	Wikidata
View/Edit Human	View/Edit Mouse

Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.

Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.

An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).