Growth hormone secretagogue receptor

GHSR
Identifiers
Aliases	GHSR, GHDP, growth hormone secretagogue receptor gene, growth hormone secretagogue receptor
External IDs	OMIM: 601898; MGI: 2441906; HomoloGene: 57161; GeneCards: GHSR; OMA:GHSR - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	172,448,456 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	27,432,159 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; islet of Langerhans; ; anterior pituitary; ; buccal mucosa cell; ; granulocyte; ; cecum; ; gonad; ; appendix; ; hypothalamus; ; blood;
	Top expressed in
	median eminence; ; arcuate nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; mammillary body; ; ventral tegmental area; ; primary visual cortex; ; neural tube; ; medulla oblongata; ; spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone binding; signal transducer activity; peptide hormone binding; growth hormone-releasing hormone receptor activity; growth hormone secretagogue receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; membrane; cell surface; neuron projection; membrane raft; plasma membrane; Schaffer collateral - CA1 synapse; postsynapse; glutamatergic synapse; integral component of synaptic membrane;
Biological process	negative regulation of interleukin-1 beta production; negative regulation of insulin secretion; regulation of synapse assembly; regulation of hindgut contraction; decidualization; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of fatty acid metabolic process; hormone-mediated signaling pathway; positive regulation of multicellular organism growth; cellular response to insulin stimulus; response to food; response to hormone; actin polymerization or depolymerization; negative regulation of inflammatory response; signal transduction; positive regulation of appetite; growth hormone secretion; adult feeding behavior; response to growth hormone; positive regulation of eating behavior; spermatogenesis; female pregnancy; learning or memory; negative regulation of norepinephrine secretion; negative regulation of appetite; response to follicle-stimulating hormone; response to estradiol; ghrelin secretion; regulation of transmission of nerve impulse; regulation of growth hormone secretion; cellular response to lipopolysaccharide; response to dexamethasone; negative regulation of locomotion involved in locomotory behavior; cellular response to thyroid hormone stimulus; positive regulation of sprouting angiogenesis; response to monosodium glutamate; regulation of gastric motility; positive regulation of vascular endothelial cell proliferation; cellular response to insulin-like growth factor stimulus; negative regulation of macrophage apoptotic process; positive regulation of growth; regulation of feeding behavior; positive regulation of small intestinal transit; positive regulation of small intestine smooth muscle contraction; G protein-coupled receptor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic modulation of chemical synaptic transmission; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	2693
	208188
	ENSG00000121853
	ENSMUSG00000051136
	Q92847
	Q99P50
	NM_198407; NM_004122
	NM_177330
	NP_004113; NP_940799
	NP_796304
	Wikidata
View/Edit Human	View/Edit Mouse

Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.