Gastric inhibitory polypeptide

GIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L71, 2B4N, 2OBU, 2QKH, 2L70, 1T5Q
Identifiers
Aliases	GIP, gastric inhibitory polypeptide
External IDs	OMIM: 137240; MGI: 107504; HomoloGene: 3043; GeneCards: GIP; OMA:GIP - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,968,596 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,921,657 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; gonad; ; testicle; ; buccal mucosa cell; ; pancreatic ductal cell; ; stromal cell of endometrium; ; sural nerve; ; placenta; ; liver;
	Top expressed in
	duodenum; ; crypt of lieberkuhn of small intestine; ; jejunum; ; intestinal epithelium; ; epithelium of small intestine; ; intestinal villus; ; embryo; ; retinal pigment epithelium; ; morula; ; corneal stroma;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity; protein binding; signaling receptor binding;
Cellular component	cytoplasm; endoplasmic reticulum lumen; extracellular region; soma; secretory granule lumen; extracellular space;
Biological process	response to selenium ion; response to amino acid; response to organic cyclic compound; digestive system development; regulation of insulin secretion; adult locomotory behavior; female pregnancy; response to peptide hormone; positive regulation of cAMP-mediated signaling; memory; response to glucose; response to lipid; response to nutrient levels; positive regulation of synaptic transmission; exploration behavior; response to axon injury; response to starvation; sensory perception of pain; positive regulation of glucagon secretion; positive regulation of glucose transmembrane transport; response to carbohydrate; triglyceride homeostasis; signal transduction; response to acidic pH; endocrine pancreas development; positive regulation of insulin secretion; long-term potentiation; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; regulation of fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2695
	14607
	ENSG00000159224
	ENSMUSG00000014351
	P09681
	P48756
	NM_004123
	NM_008119
	NP_004114
	NP_032145
	Wikidata
View/Edit Human	View/Edit Mouse

Gastric inhibitory polypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone of the secretin family of hormones. While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion.

GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins, which stimulate insulin release on oral food intake.