HLA-DQB1

HLA-DQB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JK8, 1S9V, 1UVQ, 2NNA, 4GG6
Identifiers
Aliases	HLA-DQB1, CELIAC1, HLA-DQB, IDDM1, major histocompatibility complex, class II, DQ beta 1, HLA-DRB1
External IDs	OMIM: 604305; MGI: 103070; HomoloGene: 1603; GeneCards: HLA-DQB1; OMA:HLA-DQB1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,668,383 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,488,393 bp
RNA expression pattern
	Top expressed in
	right lung; ; spleen; ; upper lobe of left lung; ; gallbladder; ; lymph node; ; monocyte; ; granulocyte; ; right coronary artery; ; rectum; ; visceral pleura;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; thymus; ; submandibular gland; ; skin of external ear; ; right lung lobe; ; lip; ; white adipose tissue; ; right kidney; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; MHC class II receptor activity; protein binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; clathrin-coated endocytic vesicle membrane; endosome; Golgi apparatus; trans-Golgi network membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; transport vesicle membrane; MHC class II protein complex; lysosomal membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; interferon-gamma-mediated signaling pathway; immunoglobulin production involved in immunoglobulin-mediated immune response; immune system process; T cell costimulation; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; humoral immune response mediated by circulating immunoglobulin; immune response; T cell receptor signaling pathway; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3119
	14961
ENSG00000233209; ENSG00000206237; ENSG00000231286; ENSG00000206302; ENSG00000179344;
	ENSG00000231939; ENSG00000225824
	ENSMUSG00000073421
	P01920
P14483; P01921; P06342; P06343; P06345;
	P06346
	NM_002123; NM_001243961; NM_001243962
	NM_207105
	NP_001230890; NP_001230891; NP_002114
	NP_996988
	Wikidata
View/Edit Human	View/Edit Mouse

Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.