Homeobox protein NANOG

NANOG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KT0
Identifiers
Aliases	NANOG, entrez:79923, Nanog, Nanog homeobox
External IDs	OMIM: 607937; MGI: 1919200; HomoloGene: 78027; GeneCards: NANOG; OMA:NANOG - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,799,146 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,691,592 bp
RNA expression pattern
	Top expressed in
	gonad; ; pericardium; ; cardia; ; thymus; ; mucosa of pharynx; ; ventral tegmental area; ; body of tongue; ; superior surface of tongue; ; trigeminal ganglion; ; synovial joint;
	Top expressed in
	blastocyst; ; epiblast; ; inner cell mass; ; morula; ; embryo; ; ureter; ; ectoderm; ; primordial germ cell; ; embryo; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; protein binding; transcription corepressor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleolus; nucleus; nucleoplasm;
Biological process	regulation of gene expression; regulation of cell differentiation; multicellular organism development; cell differentiation; cell population proliferation; regulation of transcription, DNA-templated; somatic stem cell population maintenance; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; endodermal cell fate specification; negative regulation of nucleic acid-templated transcription; stem cell population maintenance; transcription by RNA polymerase II; cytokine-mediated signaling pathway; regulation of transcription by RNA polymerase II; positive regulation of stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	79923
	71950
	ENSG00000111704
	ENSMUSG00000012396
	Q9H9S0
	Q80Z64
	NM_001297698; NM_024865
	NM_028016; NM_001289828; NM_001289830; NM_001289831
	NP_001284627; NP_079141
	NP_001276757; NP_001276759; NP_001276760; NP_082292
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein NANOG (hNanog) is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. hNanog is encoded in humans by the NANOG gene. Several types of cancer are associated with NANOG.