Hydroxycarboxylic acid receptor 3

HCAR3
Identifiers
Aliases	HCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDs	OMIM: 606039; MGI: 1933383; HomoloGene: 130547; GeneCards: HCAR3; OMA:HCAR3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,716,811 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,003,562 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; gonad; ; spleen; ; monocyte; ; mucosa of esophagus; ; bone marrow; ; skin of abdomen; ; skin of leg; ; appendix;
	Top expressed in
	granulocyte; ; esophagus; ; lip; ; skin of external ear; ; morula; ; subcutaneous adipose tissue; ; skin of back; ; transitional epithelium of urinary bladder; ; trachea; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell junction; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8843
	80885
	ENSG00000255398
	ENSMUSG00000045502
	P49019
	Q9EP66
	NM_006018
	NM_030701
	NP_006009
	NP_109626
	Wikidata
View/Edit Human	View/Edit Mouse

Hydroxycarboxylic acid receptor 3 (HCA₃), also known as niacin receptor 2 (NIACR2) and GPR109B, is a protein which in humans is encoded by the HCAR3 gene. HCA₃, like the other hydroxycarboxylic acid receptors HCA₁ and HCA₂, is a G_i/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonists of HCA₃ are 3-hydroxyoctanoic acid and kynurenic acid. HCA₃ is also a low-affinity biomolecular target for niacin (aka nicotinic acid).