Keratin 5

KRT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TNU
Identifiers
Aliases	KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A, keratin 5, EBS2E, EBS2B, EBS2C, EBS1, EBS2A, EBS2F, EBS2D
External IDs	OMIM: 148040; MGI: 96702; HomoloGene: 55461; GeneCards: KRT5; OMA:KRT5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,520,530 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,621,333 bp
RNA expression pattern
	Top expressed in
	gums; ; mucosa of pharynx; ; gingival epithelium; ; nipple; ; skin of abdomen; ; skin of arm; ; skin of thigh; ; vulva; ; human penis; ; skin of hip;
	Top expressed in
	lip; ; molar; ; skin of external ear; ; conjunctival fornix; ; skin of abdomen; ; esophagus; ; cornea; ; skin of back; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	cytoplasm; cytosol; plasma membrane; keratin filament; extracellular exosome; intermediate filament; membrane; mitochondrion; nucleus;
Biological process	hemidesmosome assembly; epidermis development; cytoskeleton organization; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3852
	110308
	ENSG00000186081
	ENSMUSG00000061527
	P13647
	Q922U2
	NM_000424
	NM_027011
	NP_000415
	NP_081287
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells. This protein is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.