Leukemia inhibitory factor

LIF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EMR, 1PVH, 2Q7N
Identifiers
Aliases	LIF, CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, interleukin 6 family cytokine, LIF interleukin 6 family cytokine
External IDs	OMIM: 159540; MGI: 96787; HomoloGene: 1734; GeneCards: LIF; OMA:LIF - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,246,759 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,222,514 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; gallbladder; ; beta cell; ; vena cava; ; mucosa of urinary bladder; ; appendix; ; pancreatic ductal cell; ; mucosa of transverse colon; ; smooth muscle tissue; ; mucosa of paranasal sinus;
	Top expressed in
	endometrium; ; Glandular part of endometrium; ; mucous gland; ; blastocyst; ; morula; ; lip; ; granulocyte; ; stroma of bone marrow; ; yolk sac; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; growth factor activity; cytokine activity; protein binding; leukemia inhibitory factor receptor binding;
Cellular component	extracellular region; extracellular space; cytosol;
Biological process	negative regulation of cell population proliferation; stem cell differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; spongiotrophoblast differentiation; lung development; positive regulation of histone H3-K27 acetylation; multicellular organism development; lung lobe morphogenesis; muscle organ morphogenesis; maternal process involved in female pregnancy; negative regulation of hormone secretion; leukemia inhibitory factor signaling pathway; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of cell differentiation; positive regulation of gene expression; stem cell population maintenance; positive regulation of peptidyl-tyrosine phosphorylation; regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of astrocyte differentiation; negative regulation of ERK1 and ERK2 cascade; neuron development; decidualization; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; lung alveolus development; positive regulation of macrophage differentiation; blood vessel remodeling; trophoblast giant cell differentiation; lung vasculature development; positive regulation of transcription by RNA polymerase II; positive regulation of protein localization to nucleus; embryo implantation; negative regulation of meiotic nuclear division; immune response; positive regulation of cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3976
	16878
	ENSG00000128342
	ENSMUSG00000034394
	P15018
	P09056
	NM_001257135; NM_002309
	NM_001039537; NM_008501
	NP_001244064; NP_002300
	NP_001034626; NP_032527
	Wikidata
View/Edit Human	View/Edit Mouse

Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.