Nicomorphine

Nicomorphine
Clinical data
Other namesMorphine dinicotinate, 3,6-dinicotinoylmorphine
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral, Intravenous, Rectal
ATC code
Legal status
Legal status
  • AU: S9 (Prohibited substance)
  • BR: Class A1 (Narcotic drugs)
  • CA: Schedule I
  • DE: Anlage I (Authorized scientific use only)
  • UK: Class A
  • US: Schedule I
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.010.326
Chemical and physical data
FormulaC29H25N3O5
Molar mass495.535 g·mol−1
3D model (JSmol)
SMILES
  • O=C(O[C@H]2\C=C/[C@H]6[C@@H]5N(CC[C@@]61c4c(O[C@H]12)c(OC(=O)c3cccnc3)ccc4C5)C)c7cccnc7
InChI
  • InChI=1S/C29H25N3O5/c1-32-13-10-29-20-7-9-23(36-28(34)19-5-3-12-31-16-19)26(29)37-25-22(8-6-17(24(25)29)14-21(20)32)35-27(33)18-4-2-11-30-15-18/h2-9,11-12,15-16,20-21,23,26H,10,13-14H2,1H3/t20-,21+,23-,26-,29-/m0/s1 Y
  • Key:HNDXBGYRMHRUFN-CIVUWBIHSA-N Y
 NY (what is this?)  (verify)

Nicomorphine (Vilan, Subellan, Gevilan, MorZet) is the 3,6-dinicotinate ester of morphine. It is a strong opioid agonist analgesic two to three times as potent as morphine with a side effect profile similar to that of dihydromorphine, morphine, and diamorphine.

Nicomorphine was first synthesized in 1904 and was patented as Vilan by Lannacher Heilmittel G.m.b.H. of Austria in 1957.