PF-04455242

PF-04455242
Clinical data
Other names	PF-4455242; PF04455242; PF4455242
Routes of; administration	Oral
Drug class	κ-Opioid receptor antagonist
ATC code	None;
Identifiers
	IUPAC name 2-methyl-N-[[4-(2-pyrrolidin-1-ylsulfonylphenyl)phenyl]methyl]propan-1-amine;
CAS Number	1202647-54-8;
PubChem CID	44599828;
ChemSpider	26610764;
UNII	Y3530Z78QD;
ChEMBL	ChEMBL1818341;
CompTox Dashboard (EPA)	DTXSID30152783 ;
Chemical and physical data
Formula	C21H28N2O2S
Molar mass	372.53 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)CNCC1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)N3CCCC3;
	InChI InChI=1S/C21H28N2O2S/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3; Key:OWVIKBRKPCTDEP-UHFFFAOYSA-N;

PF-04455242 is an experimental κ-opioid receptor (KOR) antagonist which was under development by Pfizer for the treatment of bipolar depression but was never marketed. Its development was discontinued in early clinical trials. It is taken by mouth.

Clinical data

Other names	PF-4455242; PF04455242; PF4455242
Routes of administration	Oral
Drug class	κ-Opioid receptor antagonist
ATC code	None
Identifiers
IUPAC name 2-methyl-N-[[4-(2-pyrrolidin-1-ylsulfonylphenyl)phenyl]methyl]propan-1-amine
CAS Number	1202647-54-8
PubChem CID	44599828
ChemSpider	26610764
UNII	Y3530Z78QD
ChEMBL	ChEMBL1818341
CompTox Dashboard (EPA)	DTXSID30152783
Chemical and physical data
Formula	C₂₁H₂₈N₂O₂S
Molar mass	372.53 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)CNCC1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)N3CCCC3
InChI InChI=1S/C21H28N2O2S/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3 Key:OWVIKBRKPCTDEP-UHFFFAOYSA-N