Protein S

PROS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z6C
Identifiers
Aliases	PROS1, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, protein S (alpha), protein S
External IDs	OMIM: 176880; MGI: 1095733; HomoloGene: 264; GeneCards: PROS1; OMA:PROS1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	93,980,003 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	62,749,709 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; bronchial epithelial cell; ; synovial joint; ; germinal epithelium; ; parietal pleura; ; pericardium; ; liver; ; visceral pleura; ; spinal ganglia; ; trigeminal ganglion;
	Top expressed in
	cumulus cell; ; decidua; ; stroma of bone marrow; ; aortic valve; ; endothelial cell of lymphatic vessel; ; gastrula; ; iris; ; calvaria; ; left lung lobe; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; endopeptidase inhibitor activity;
Cellular component	blood microparticle; endoplasmic reticulum membrane; Golgi membrane; plasma membrane; extracellular region; Golgi lumen; extracellular exosome; platelet alpha granule lumen; extracellular space;
Biological process	hemostasis; fibrinolysis; platelet degranulation; blood coagulation; endoplasmic reticulum to Golgi vesicle-mediated transport; signal peptide processing; peptidyl-glutamic acid carboxylation; regulation of complement activation; leukocyte migration; negative regulation of endopeptidase activity; negative regulation of blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	5627
	19128
	ENSG00000184500
	ENSMUSG00000022912
	P07225
	Q08761
	NM_000313; NM_001314077
	NM_011173
	NP_000304; NP_001301006
	NP_035303
	Wikidata
View/Edit Human	View/Edit Mouse

Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene. Protein S plays a role in coagulation.