| PROZ |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | PROZ, PZ, Protein Z, protein Z, vitamin K dependent plasma glycoprotein |
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| External IDs | OMIM: 176895; MGI: 1860488; HomoloGene: 2890; GeneCards: PROZ; OMA:PROZ - orthologs |
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| Gene location (Human) |
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| | Chr. | Chromosome 13 (human) |
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| | Band | 13q34 | Start | 113,158,648 bp |
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| End | 113,172,386 bp |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 8 (mouse) |
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| | Band | 8|8 A1.1 | Start | 13,110,914 bp |
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| End | 13,126,026 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right lobe of liver
- kidney tubule
- glomerulus
- metanephric glomerulus
- human kidney
- mucosa of transverse colon
- right testis
- cerebellar hemisphere
- right hemisphere of cerebellum
- pituitary gland
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| | Top expressed in | - liver
- left lobe of liver
- yolk sac
- granulocyte
- epithelium of small intestine
- right kidney
- duodenum
- dentate gyrus of hippocampal formation granule cell
- superior frontal gyrus
- primary visual cortex
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | | | Cellular component | | | Biological process | | | Sources:Amigo / QuickGO |
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| Wikidata |
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Protein Z (PZ or PROZ), vitamin K-dependent protein Z, is a protein encoded in the human by the PROZ gene.
Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is a glycoprotein. Protein Z functions to inhibit blood coagulation by binding to an inhibitor. It is a GLA domain protein and thus Vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy.
