Resistin

RETN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LV6
Identifiers
Aliases	RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin
External IDs	OMIM: 605565; MGI: 1888506; HomoloGene: 10703; GeneCards: RETN; OMA:RETN - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,670,455 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,710,110 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; monocyte; ; trabecular bone; ; granulocyte; ; right lung; ; upper lobe of left lung; ; blood; ; spleen; ; gastric mucosa;
	Top expressed in
	white adipose tissue; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; lactiferous gland; ; intercostal muscle; ; tunica media of zone of aorta; ; mesenteric lymph nodes; ; brown adipose tissue; ; ankle joint; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular exosome; nucleus; extracellular region; extracellular space; azurophil granule lumen; specific granule lumen;
Biological process	positive regulation of smooth muscle cell migration; response to insulin; positive regulation of progesterone secretion; response to mechanical stimulus; ageing; positive regulation of collagen metabolic process; fat cell differentiation; positive regulation of synaptic transmission; negative regulation of feeding behavior; positive regulation of smooth muscle cell proliferation; neutrophil degranulation; regulation of signaling receptor activity; biological process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	56729
	57264
	ENSG00000104918
	ENSMUSG00000012705
	Q9HD89
	Q99P87
	NM_020415; NM_001193374; NM_001385725; NM_001385726; NM_001385727
	NM_001204959; NM_022984
	NP_001180303; NP_065148
	NP_001191888; NP_075360
	Wikidata
View/Edit Human	View/Edit Mouse

Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1), is a cysteine-rich peptide hormone that is derived from adipose tissue and, in humans, is encoded by the RETN gene.

In primates, pigs, and dogs, resistin is secreted primarily by immune and epithelial cells, whereas in rodents, it is mainly secreted by adipose tissue. The human resistin pre-peptide consists of 108 amino acid residues, while in mice and rats it is 114 amino acids in length; the molecular weight is approximately 12.5 kDa. Resistin is classified as an adipose-derived hormone (similar to a cytokine), and its physiological role has been widely debated, particularly regarding its involvement in obesity and type II diabetes mellitus (T2DM).