Steroid 11β-hydroxylase

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NCBI	proteins

steroid 11β-monooxygenase
steroid 11β-monooxygenase
Identifiers
EC no.	1.14.15.4
CAS no.	9029-66-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

CYP11B1
Identifiers
Aliases	CYP11B1, CPN1, CYP11B, FHI, P450C11, cytochrome P450 family 11 subfamily B member 1
External IDs	OMIM: 610613; MGI: 88584; HomoloGene: 128035; GeneCards: CYP11B1; OMA:CYP11B1 - orthologs
EC number	1.14.15.4
Gene location (Human)
Chr.	Chromosome 8 (human)
End	142,879,846 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	74,728,167 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; testicle; ; pancreatic ductal cell; ; right testis; ; right coronary artery; ; left testis; ; metanephros; ; ectocervix;
	Top expressed in
	adrenal gland; ; lumbar subsegment of spinal cord; ; lumbar spinal ganglion; ; vastus lateralis muscle; ; spermatid; ; carotid body; ; gastrula; ; thoracic diaphragm; ; triceps brachii muscle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; corticosterone 18-monooxygenase activity; metal ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; steroid 11-beta-monooxygenase activity; heme binding;
Cellular component	membrane; mitochondrial membranes; mitochondrion; mitochondrial inner membrane;
Biological process	glucose homeostasis; lipid metabolism; aldosterone biosynthetic process; cortisol biosynthetic process; regulation of blood pressure; C21-steroid hormone biosynthetic process; cellular response to hormone stimulus; glucocorticoid biosynthetic process; immune response; sterol metabolic process; cellular response to potassium ion; steroid biosynthetic process; steroid metabolic process; cholesterol metabolic process; cellular response to peptide hormone stimulus; cortisol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1584
	13072
	ENSG00000160882
	ENSMUSG00000022589
	P15538
	P15539
	NM_000497; NM_001026213
	NM_009991
	NP_000488; NP_001021384
	NP_034121
	Wikidata
View/Edit Human	View/Edit Mouse

Steroid 11β-hydroxylase, also known as steroid 11β-monooxygenase, is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata of the adrenal cortex. Named officially the cytochrome P450 11B1, mitochondrial, it is a protein that in humans is encoded by the CYP11B1 gene. The enzyme is involved in the biosynthesis of adrenal corticosteroids by catalyzing the addition of hydroxyl groups during oxidation reactions.