Thymic stromal lymphopoietin

TSLP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NN5, 4NN6, 4NN7
Identifiers
Aliases	TSLP, thymic stromal lymphopoietin
External IDs	OMIM: 607003; MGI: 1855696; HomoloGene: 81957; GeneCards: TSLP; OMA:TSLP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	111,078,026 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	32,952,850 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; gallbladder; ; cartilage tissue; ; right lobe of liver; ; right ventricle; ; myocardium of left ventricle; ; apex of heart; ; urinary bladder; ; prostate; ; right coronary artery;
	Top expressed in
	embryo; ; embryo; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; zygote; ; Paneth cell; ; right lung; ; right lung lobe; ; secondary oocyte; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; interleukin-7 receptor binding;
Cellular component	extracellular space; extracellular region;
Biological process	regulation of signaling receptor activity; interleukin-7-mediated signaling pathway; positive regulation of cytokine-mediated signaling pathway; positive regulation of cell population proliferation; positive regulation of chemokine production; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of mast cell activation; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of apoptotic process; positive regulation of inflammatory response; defense response to Gram-negative bacterium; defense response to fungus; antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of chemokine (C-C motif) ligand 1 production; positive regulation of granulocyte colony-stimulating factor production; positive regulation of receptor signaling pathway via STAT;
	Sources:Amigo / QuickGO
Orthologs
	85480
	53603
	ENSG00000145777
	ENSMUSG00000024379
	Q969D9
	Q9JIE6
	NM_033035; NM_138551
	NM_021367
	NP_149024; NP_612561
	NP_067342
	Wikidata
View/Edit Human	View/Edit Mouse

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the immune system. It shares a common ancestor with IL-7.

Originally appreciated for its role in immune cell proliferation and development, and then for its pivotal role in type 2 immune responses, TSLP is now known to be involved in other types of immune responses, autoimmune disease, and certain cancers.