VLDL receptor

VLDLR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V9U, 3DPR
Identifiers
Aliases	VLDLR, CAMRQ1, CARMQ1, CHRMQ1, VLDLRCH, VLDL-R, very low density lipoprotein receptor
External IDs	OMIM: 192977; MGI: 98935; HomoloGene: 443; GeneCards: VLDLR; OMA:VLDLR - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	2,660,056 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	27,254,231 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; left ovary; ; right ovary; ; myocardium of left ventricle; ; islet of Langerhans; ; cardiac muscle tissue of right atrium; ; right auricle of heart; ; gingival epithelium; ; biceps brachii; ; body of pancreas;
	Top expressed in
	decidua; ; retinal pigment epithelium; ; ankle; ; vas deferens; ; right ventricle; ; molar; ; sternocleidomastoid muscle; ; digastric muscle; ; body of femur; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	low-density lipoprotein particle receptor activity; reelin receptor activity; calcium ion binding; apolipoprotein binding; protein binding; very-low-density lipoprotein particle binding; calcium-dependent protein binding; very-low-density lipoprotein particle receptor activity; cargo receptor activity;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; very-low-density lipoprotein particle; clathrin-coated pit; extracellular space; lysosomal membrane;
Biological process	steroid metabolic process; lipid transport; endocytosis; dendrite morphogenesis; lipid metabolism; glycoprotein transport; cholesterol metabolic process; negative regulation of transcription by RNA polymerase II; memory; positive regulation of dendrite development; receptor-mediated endocytosis; nervous system development; ventral spinal cord development; reelin-mediated signaling pathway; transport; signal transduction; positive regulation of protein kinase activity; axon guidance; low-density lipoprotein particle receptor catabolic process; very-low-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologs
	7436
	22359
	ENSG00000147852
	ENSMUSG00000024924
	P98155
	P98156
	NM_001018056; NM_003383; NM_001322225; NM_001322226
	NM_001161420; NM_013703; NM_001347441
	NP_001018066; NP_001309154; NP_001309155; NP_003374
	NP_001154892; NP_001334370; NP_038731
	Wikidata
View/Edit Human	View/Edit Mouse

The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by Tokuo. Yamamoto and Sadao. Takahashi, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apolipoprotein E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.