Viperin

RSAD2
Identifiers
Aliases	RSAD2, 2510004L01Rik, cig33, cig5, vig1, radical S-adenosyl methionine domain containing 2, Viperin Protein, Viperin
External IDs	OMIM: 607810; MGI: 1929628; HomoloGene: 10969; GeneCards: RSAD2; OMA:RSAD2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	6,898,239 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	26,506,451 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; decidua; ; monocyte; ; bronchial epithelial cell; ; palpebral conjunctiva; ; Achilles tendon; ; retinal pigment epithelium; ; trabecular bone; ; amniotic fluid; ; right uterine tube;
	Top expressed in
	blood; ; tibiofemoral joint; ; body of femur; ; spleen; ; mucous cell of stomach; ; bone marrow; ; endothelial cell of lymphatic vessel; ; lumbar spinal ganglion; ; right ventricle; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; metal ion binding; protein self-association; catalytic activity; protein binding;
Cellular component	Golgi apparatus; endoplasmic reticulum membrane; membrane; lipid droplet; mitochondrial outer membrane; endoplasmic reticulum; mitochondrion; mitochondrial inner membrane; fibrillar center;
Biological process	CD4-positive, alpha-beta T cell differentiation; CD4-positive, alpha-beta T cell activation; immune system process; response to virus; positive regulation of toll-like receptor 7 signaling pathway; negative regulation of viral genome replication; defense response to virus; type I interferon signaling pathway; positive regulation of toll-like receptor 9 signaling pathway; innate immune response; viral process; positive regulation of T-helper 2 cell cytokine production; negative regulation of protein secretion;
	Sources:Amigo / QuickGO
Orthologs
	91543
	58185
	ENSG00000134321
	ENSMUSG00000020641
	Q8WXG1
	Q8CBB9
	NM_080657
	NM_021384
	NP_542388
	NP_067359
	Wikidata
View/Edit Human	View/Edit Mouse

Radical S-adenosyl methionine domain-containing protein 2 is a protein that in humans is encoded by the RSAD2 gene. RSAD2 is a multifunctional protein in viral processes that is an interferon stimulated gene. It has been reported that viperin could be induced by either IFN-dependent or IFN-independent pathways and certain viruses may use viperin to increase their infectivity.

The protein was previously called virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (viperin). The name viperin has been rectified due to inappropriate use of it to describe homologous prokaryotic enzymes producing nucleotide analogues. The enzymes across all domains of life are renamed SAM-dependent nucleotide dehydratase (SAND) using NC-IUBMB recommendations.