The popular statement, " From here to Timbuktu." conjures up images of remote, isolated and distant parts of this earth. The actual Timbuktu is in Mali, but Wikitravel doesn't offer much in terms of getting there.

Obviously it's remote, in some ways it's 'the ultimate destination' for people looking to get lost in isolated places. I've only met one person who has been there, and his trip involved several vehicles and camels(!).
So let's take a starting point reasonably far away - Vancouver, Canada. Where I happen to be right now. I'm considering a NW Africa trip next year, and if I do, I'd dearly love to get to Timbuktu. What would be the most efficient / sensible way of getting there, while on a minimal budget?