Cortistatin (neuropeptide)

CORT
Identifiers
Aliases	CORT, CST-14, CST-17, CST-29, cortistatin, SST2
External IDs	OMIM: 602784; MGI: 109538; HomoloGene: 997; GeneCards: CORT; OMA:CORT - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	10,451,998 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,211,220 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; prefrontal cortex; ; nucleus accumbens; ; superior frontal gyrus; ; anterior cingulate cortex; ; gonad; ; temporal lobe; ; amygdala; ; Brodmann area 9;
	Top expressed in
	embryo; ; primary visual cortex; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; hippocampus proper; ; fetal liver hematopoietic progenitor cell; ; perirhinal cortex; ; tail of embryo; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity; G protein-coupled receptor binding; hormone activity; chromatin binding; double-stranded DNA binding;
Cellular component	extracellular region; Fanconi anaemia nuclear complex; FANCM-MHF complex; extracellular space;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; chemical synaptic transmission; mitotic recombination; resolution of meiotic recombination intermediates; interstrand cross-link repair; replication fork processing; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1325
	12854
	ENSG00000241563
	ENSMUSG00000028971
	O00230
	P56469
	NM_001302
	NM_007745
	NP_001293
	NP_031771
	Wikidata
View/Edit Human	View/Edit Mouse

Precortistatin is a protein that in humans is encoded by the CORT gene. The 105 amino acid residue human precortistatin in turn is cleaved into cortistatin-17 and cortistatin-29. Cortistatin-17 is the only active peptide derived from the precursor. Cortistatin (or more specifically cortistatin-17) is a neuropeptide that is expressed in inhibitory neurons of the cerebral cortex, and which has a strong structural similarity to somatostatin. Unlike somatostatin, when infused into the brain, it enhances slow-wave sleep. It binds to sites in the cortex, hippocampus and the amygdala.